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Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases

Identifieur interne : 000880 ( Main/Exploration ); précédent : 000879; suivant : 000881

Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases

Auteurs : T. Hanada [Japon] ; I. Kinjyo [Japon] ; K. Inagaki-Ohara [Japon] ; A. Yoshimura [Japon]

Source :

Reviews of Physiology, Biochemistry and Pharmacology [ 0303-4240 ] ; 2004.

RBID : ISTEX:26FFE5C15AFD32A9CB31EB78B9444C56F6B8E541

Abstract

Abstract: Hematopoiesis, the process of Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

Url:

https://api.istex.fr/document/26FFE5C15AFD32A9CB31EB78B9444C56F6B8E541/fulltext/pdf

DOI: 10.1007/s10254-003-0015-z

Affiliations:

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Le document en format XML

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Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases

Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri